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Offre de thèse: Modélisation de la torsion de l’ADN dans la régulation de l’expression des gènes

Type d'annonce : Offre de thèse

De : MAP UMR5240 , Lyon - site internet

This thesis is part of an international collaboration with the Xiao lab at Johns Hopkins University (Baltimore, USA) and will involve international travels funded by an ANR grant.

We are looking for a student highly interested in interdisciplinary research, who will develop computational models and simulations of the interplay between transcription and DNA torsion (supercoiling), a fundamental physical property of the double-helix. This interplay is dynamic and double-sided, since transcription is both affected by (1) and generates torsional stress dynamically (2,3). This torsion propagates along the DNA, resulting in an interaction between neighboring genes that affects all organisms but escapes usual biological models (1,2), providing a deep relation between the physical state and the biological function of the genome (4). The candidate will develop stochastic simulations of the system and statistical analyses of experimental data provided by collaborators (from microscopy and high-throughput omics technologies), to confirm and quantify the investigated mechanism. Depending on the candidate’s skills and preferences, more emphasis can be put toward physical modeling, computational simulation or statistical data analysis.

[1] Pineau et al. (2025), NAR 53, https://doi.org/10.1093/nar/gkaf452

[2] Forquet et al. (2022), NAR 50, 7287-7297, https://doi.org/10.1093/nar/gkac579

[3] El Houdaigui et al. (2019), NAR 46, 5648-5657, https://doi.org/10.1093/nar/gkz300

[4] Martis et al. (2019), CSBJ 17, 1047-1055, https://doi.org/10.1016/j.csbj.2019.07.013

Détails de l'annonce

  • Profil : Modélisation et simulation numérique, biophysique, bioinformatique, programmation
  • Durée de contrat : 3 ans
  • Date de prise de fonction : Au plus tard en octobre 2026
  • Documents à fournir pour candidater : CV, Lettre de recommandation
  • Date limite de candidature : 01/07/2026

Personne à contacter

  • Nom : Sam Meyer
  • Email : sam.meyer@insa-lyon.fr