Postdoc 12 mois AFM et microscopie d’expansion mode d’action toxine Candidalysine CBMN Bordeaux
Type d'annonce : Offre d'emploi post-doctorat
De : CBMN , Pessac - site internet
Candidalysin is the first cytolytic peptide toxin isolated from a human fungal pathogen. In the case of Candida albicans, the main causal agent of infections, candidalysine production induces i) the formation of pores in host cell membranes that lead to cell lysis and ii) the inflammasome reaction which activates the immune response. Whereas the final effects of this toxin are well described, the underlying mechanisms and molecular interactions governing its activity are not yet totally understood. This is mostly due to the underuse of approaches giving access to high resolution imaging and molecular sensing. Filling this gap requires the combination of innovative methods at the interface between biology, biophysics and physico-chemistry. In this project, we will use atomic force microscopy (AFM), force spectroscopy and expension microscopy approaches to probe the interactions at the nanometric and molecular scales and decipher the mode of action of this toxin.
Détails de l'annonce
- Durée de contrat : 12 mois
- Date de prise de fonction : Janvier 2025
- Documents à fournir pour candidater : CV, Lettre de motivation
- Date limite de candidature : 29/11/2024
Personne à contacter
- Nom : Sofiane El Kirat Chatel
- Email : sofiane.elkirat@u-bordeaux.fr